◆ Non aerosol aerosol production - enhances biosafety (for mycobacteria, viruses) ◆ eliminates the risk of sample cross contamination
◆ Eliminates the complexity of traditional hand-held probe and fixed probe ◆ Very little foam
◆ Automatic power switch, no adjustment knob ◆ Can handle various samples, with a wide range of sample processing
◆ Suitable for various standard containers (PCR tubes, Eppendorf tube, 15mL Corning/Falcon tubes) ◆ capable of processing 12 samples at once
◆ Can be used to process trace samples up to 5L ◆ The automatic continuous rotation centrifuge tube makes the energy distribution of ultrasound more uniform

	BIoruptor ultrasonic device	Probe type ultrasonic instrument
Applicability	Wide application range, can be applied to: ChIP assay, High throughput sequencer sample preprocessing, bacterial fragmentation, cell fragmentation, membrane protein extraction, homogenization, emulsification reaction	approve
Fragment size	DNA can be fragmented into ideal sizes, such as: ChIP assay: 300~500bp, High throughput sequencer: 150~250bp, High concentration of DNA fragments	The uncontrollable size of DNA fragmentation can easily generate large areas of smear DNA fragments
Sample rack	Various types of sample racks are available, including 0.5ml commonly used in experiments, 1.5ml, 15ml, 50ml centrifuge tubes paired with each other	not have
flux	High throughput, capable of processing 24 samples at once (UCD-400, 0.5ml sample rack)	Only one sample can be processed at a time
Sample result repeatability	Under the same experimental conditions, high repeatability ultrasound results can be obtained by using a rotating sample holder with high ultrasonic frequency	Low repeatability between samples
Interactive contamination between samples	Non probe sealed ultrasound method ensures no cross contamination of the sample	Probe type, if the probe cleaning is not complete, the samples are prone to cross contamination
safety	Closed tube ultrasound does not produce infectious flying mist, ensuring the safety of laboratory personnel and the environment	Need to open the tube for ultrasound, which can easily produce infectious flying mist
Sample bubble production	Completely non foaming, protein is not easily denatured, and will not degrade or harm the sample	High heat generation near the probe, easy bubble formation, and high possibility of protein denaturation
Suitable for precious samples	Capable of handling 5ul of samples, suitable for precious samples	If the sample is too small, the probe type ultrasonic instrument cannot be used

UCD-200	Next Gen UCD-300	TWIN UCD-400	XL UCD-500
Single sink	Single sink	Double sink type	Single large sink
Number of samples that can be uploaded at once: 0.5ml: 12 samples 1.5ml: 6 samples 15ml: 6 samples 50ml: 3 samples	Number of samples that can be uploaded at once: 0.5ml: 12 samples 1.5ml: 6 samples 15ml: 6 samples 50ml: 3 samples	Number of samples that can be uploaded at once: 0.5ml: 24 samples 1.5ml: 12 samples 15ml: 12 samples 50ml: 6 samples	Number of samples that can be uploaded at once: 0.5ml: 48 samples 1.5ml: 24 samples 15ml: 24 samples 50ml: 12 samples
Plastic noise resistant speaker	Metal anti noise speaker with excellent sound insulation effect	Metal anti noise speaker with excellent sound insulation effect	Metal anti noise speaker with excellent sound insulation effect
Rotary timer (analog)	Digital Timer	Digital Timer	Digital Timer
_	Equipped with overheat automatic protection device	Equipped with overheat automatic protection device	Equipped with overheat automatic protection device
L. M, H three power options	L. Two power options for H	L. M, H three power options	L. M1, M2, H four power options
Main functions: DNA, chromatin shearing	Main functions: DNA, chromatin shearing	Main functions: DNA, chromatin shearing	Main functions: Cell lysis

1. Wide application range: can be applied to: ChIP assay, High throughput sequencer sample pre-processing, homogenization, bacterial fragmentation, cell fragmentation, membrane protein extraction, emulsification reaction, etc
2. Fragment size: DNA can be fragmented into ideal sizes, such as: ChIP assay: 300~500bp, High throughput sequencer: 150~250bp, High concentration of DNA fragments
3. High throughput: 6-12 samples can be processed at once
4. Sample rack: Various types of sample racks are available, including 0.5ml commonly used in experiments, 1.5ml, 15ml, 50ml centrifuge tubes paired with each other
5. High repeatability of sample results: By rotating the sample holder while ultrasound, highly reproducible ultrasound results can be obtained under the same experimental conditions
6. Avoid cross contamination between samples: Due to the use of a probe free closed ultrasound method, the samples will not cross contaminate
7. High safety: ensuring the safety of laboratory personnel and environment, closed tube ultrasound, no infectious flying mist produced